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Department of Biotechnology Anna University

Dr. Tamilselvan Jayavelu


Assistant Professor,

Department of Biotechnology

Anna University, Chennai 600025


044 - 2235 8390

tamilselvan@annauniv.edu








Education

Degree Year University Major Subject Studied
Ph D Mar 2008 Dr. AL Mudaliar Post-Graduate Institute of Basic Medical Sciences, Taramani Campus, University of Madras Biochemistry
M.Sc Apr 2002 Dr. AL Mudaliar Post-Graduate Institute of Basic Medical Sciences, Taramani Campus, University of Madras Biochemistry
B.Sc Apr 2000 University of Madras Biochemistry

Lectures


2017- “Effects of insulin signaling on mitochondrial turnover by targeting autophagy and mitochondrial biogenesis" in 5th International Conference on Molecular Signaling organized by AU-KBC Research Centre, MIT Campus, Anna University, Green Coconut Resort, ECR, Chennai
2014- “Unaided autophagy is not sufficient to determine mitochondrial quality control in adipose tissue of diet-induced diabetic mice" in 38th Mahabaleshwar seminar on Mitochondria, Metabolism and Energetics organized by TIFR, Mumbai, Mahabaleshwar, India.
2012- "Organelle turnover signaling" in Evolutionary Trends in Biochemistry and Molecular Biology Biotrendz 2012 organized by Department of Biochemistry, Bharathidasan University, Trichy.






Current research


•Centre for Biotechnology, Anna University, Chennai-600025, India (2010 – till date) – Cellular response to extracellular cues depends upon its intracellular status as well as the availability other molecules as exemplified by the presence of insulin with absence of effects during insulin resistance. Hence, our group is attempting to understand the role of nutrients and manipulated intracellular environments on directing insulin signals.


Post-Doctoral research


• Department of Pharmaceutical & Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, SC, USA (2009 – 10) – To evaluate the effect and mechanism of serotonin receptor agonists on mitochondrial biogenesis using primary cultures of renal proximal tubular cells.

• Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA (2008 – 09) – To elucidate the mitochondrial respiratory stress signaling in cancer with a new perspective about the distinctive nature of NFкB (cRel:p50) activation in transgenic mice and c2c12 skeletal myoblast cell culture model.


Doctoral research


• Department of Medical Biochemistry, Dr. ALM PG IBMS, University of Madras, Chennai, India (2003 – 2008) – To evaluate the effects of L-Carnitine and DL-α-Lipoic acid on mitochondrial Bioenergetics with Special Reference to Cytochrome c Oxidase and Apoptosis in Skeletal Muscle of Aged Rats


Sponsored Research Projects


S.No Project details Agency Status
1 Autophagy influences hyperglycemia/ hyperinsulinemia induced adipocyte dysfunction: A possible mechanism of insulin resistance DBT Completed
2. Dysregulation of autophagy influences mitochondria function and biogenesis in adipocytes: A Fundamental approach to insulin resistance. SERB Completed
3. Hyperinsulinemia influences autophagy and mitochondrial biogenesis: A possible mechanism of neuronal ageing ICMR Completed
4. Hyperinsulinemia influences autophagy and endoplasmic reticulum turnover in ageing UGC Completed
5. Differential anaplerotic flux of amino acids influences insulin sensitivity: Role of biotin on biosynthetic capacity of the cell SERB On-going




Research Publications


  • Periyasamy S, Sathya M, Karthick C, Kandasamy M, Shanmugaapriya S, Tamilselvan J, Jayachandran KS, Anusuyadevi M (2017). Association Studies of Specific Cholesterol Related Genes (APOE, LPL, and CETP) with Lipid Profile and Memory Function: A Correlative Study Among Rural and Tribal Population of Dharmapuri District, J Alzheimers Dis 60, S195-S207
  • Rasbach KA, Funk JA, Jayavelu T, Green PT, Schnellmann RG (2010). 5-hydroxytryptamine receptor stimulation of mitochondrial biogenesis. J Pharmacol Exp Ther 332 (2), 632-639.
  • Tamilselvan J, Jayaraman G, Sivarajan K, Panneerselvam C (2007). Age dependent upregulation of p53 and cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: Role of carnitine and lipoic acid. Free Radic Biol Med 43(12), 1656-1669.
  • Tamilselvan J, Sivarajan K, Anusuyadevi M, Panneerselvam C (2007) Cytochrome c Oxidase Rather than Cytochrome c is a Major Determinant of Mitochondrial Respiratory Capacity in Skeletal Muscle of Aged Rats: Role of Carnitine and Lipoic Acid. Rejuvenation Res 10(3), 311-326.




    Contact


    Assistant Professor, Centre for Biotechnology

    Department of Biotechnology

    Anna University, Chennai 600025

    tamilselvan@annauniv.edu, tmlsln.j@gmail.com

    044 - 2235 8390, 91 9841656368