•Centre for Biotechnology, Anna University, Chennai-600025, India (2010 – till date) – Cellular response to extracellular cues depends upon its intracellular status as well as the availability other molecules as exemplified by the presence of insulin with absence of effects during insulin resistance. Hence, our group is attempting to understand the role of nutrients and manipulated intracellular environments on directing insulin signals.
• Department of Pharmaceutical & Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, SC, USA (2009 – 10) – To evaluate the effect and mechanism of serotonin receptor agonists on mitochondrial biogenesis using primary cultures of renal proximal tubular cells.
• Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA (2008 – 09) – To elucidate the mitochondrial respiratory stress signaling in cancer with a new perspective about the distinctive nature of NFкB (cRel:p50) activation in transgenic mice and c2c12 skeletal myoblast cell culture model.
• Department of Medical Biochemistry, Dr. ALM PG IBMS, University of Madras, Chennai, India (2003 – 2008) – To evaluate the effects of L-Carnitine and DL-α-Lipoic acid on mitochondrial Bioenergetics with Special Reference to Cytochrome c Oxidase and Apoptosis in Skeletal Muscle of Aged Rats
|1||Autophagy influences hyperglycemia/ hyperinsulinemia induced adipocyte dysfunction: A possible mechanism of insulin resistance||DBT||Completed|
|2.||Dysregulation of autophagy influences mitochondria function and biogenesis in adipocytes: A Fundamental approach to insulin resistance.||SERB||Completed|
|3.||Hyperinsulinemia influences autophagy and mitochondrial biogenesis: A possible mechanism of neuronal ageing||ICMR||Completed|
|4.||Hyperinsulinemia influences autophagy and endoplasmic reticulum turnover in ageing||UGC||Completed|
|5.||Differential anaplerotic flux of amino acids influences insulin sensitivity: Role of biotin on biosynthetic capacity of the cell||SERB||On-going|
Assistant Professor, Centre for Biotechnology
Department of Biotechnology
Anna University, Chennai 600025
044 - 2235 8390, 91 9841656368