• Studying the first leading cell of angiogenesis using eNOS GFP transgenic Zebrafish (DST) 2016-2019. Budget 66 Lakh
• Nitric oxide in hepatocellular carcinoma: mechanisms and therapeutic implications (DST 2015-2018). Budget 40 Lakh.
• RUBICON European Union – Horizon 2020 (2016-2019) Euro 135,000RUBICON is an EU-funded Research and Innovation Staff Exchange network supported with funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 690850. Chatterjee Lab has joined a worldwide network called RUBICON, funded by the European Commission (EC), for studying the pathology of tendons, cartilage, bone and blood vessels. The RUBICON Network project has nine other institutions from four continents as participants under the EC’s Horizon 2020 program, coordinated by the University of L'Aquila, Italy. The project involves 5 European institutions (the Universities of L'Aquila, Italy, Newcastle and Manchester, UK and Erasmus MC, Rotterdam, The Netherlands and Rigshospitalet, Glostrup, Copenhagen, Denmark) and 5 non-European (the University of Cape Town, South Africa, ICAHN School of Medicine at Mount Sinai, New York, USA, Anna University, Chennai, India and the University of Hong Kong, Hong Kongand the Australian Murdoch Children's Research Institute).
• European Union – Marie Curie FP7 Project (2011-2015) Euro 63,000. The interplay among bone cells, matrices and systems (INTERBONE) FP7-PEOPLE-2011-IRSES; Grant No 295181. A group of six laboratories from six nations across the globe will be participating in this research initiative. The objective of the project is to investigate into the cross talk among bone cells, matrices and other physiological components. We envisage that the outcome of the program will offer faster and effective healing of damaged bones.
Our goal is to understand the mechanism of tumor derived cytokines recruits and regulates the fate of infiltrating stem cells and how these cells affect tumor progression. We are focused in genetic and metabolic profiling that occur in tumor and MSCs.
• Study of dermal microvascular endothelial cells in relation to selected skin perturbing candidates. Unilever Limited (2011-2013)
• 40 M. Sc students – completed, 1981-2003
• 45 B. Tech students – completed, 2008 – till date
• 28 M Tech students – completed, 2007 – till date
• 2 MS (By Research) – completed, 2007 – till date
• 11 PhD students – completed, 2008 – till date
• Development and validation of a Cell-tissue co-culture model for aiding liver specific studies and drug discovery applications (Department of Biotechnology DBT 2012-2015) Budget 24 Lakh
• Application of microgravity assisted endothelial tubes in wound healings (Department of Biotechnology DBT 2012-2015) Budget 31.42 Lakh
• Dissecting signaling mechanism of sFRP4 mediated inhibition of angiogenesis (Department of Biotechnology (DBT) 2010-2014
• Development of chick embryo model for ischemia diseases (Indian Council of Medical Research-ICMR) 2011-1014
• Targeting organosulphur as a drug for high altitude induced pulmonary edema. Defence Research and Development Organization (DRDO) 2010-2013
• Study on microgravity induced signaling mechanisms of angiogenesis (Council of Scientific and Industrial Research (CSIR) 2010-2013
• 11th 5 Year Plan Programme entitled “Human performance under different operational environments” Defence Research and Development Organization (DRDO) (2009-2014)
• Interaction of Leptin with endothelium and it’s implication in angiogenesis (Department of Science and Technology (DST) 2010-2013
• Studying the effects of mToR inhibitor and Sunitinib on Hepatic Stellate Cells. Indo-Swiss Joint Project (DST) (2008-2011)
• Mechanistic analysis of cadmium-induced cardiovascular diseases (Indian Council of Medical Research-ICMR) 2010-1013.
• Proteome study of the cadmium perturbations in nitric oxide signaling. BRNS-DAE (2009-2012)
• Dissecting nitric oxide signaling pathways of hypoxia induced tissue remodeling in lungs (Life Science Research Board LSRB, Defence Research and Development Organization (DRDO))
• Studying the mechanism of cadmium mediated suppression of nitric oxide production in endothelial cells: Implications in endothelial cell biology. (Indian Council of Medical Research (ICMR)
•Use of nitric oxide in reversing pathologic fibrogenesis in liver: A cell biology approach to cure liver cirrhosis (The Academy of Sciences for the Developing World – TWAS)
•Dissecting the molecular mechanism of endothelial nitric oxide synthase translocation (Department of Science and Technology (DST)). 2009
•Implication of shear stress-mediated production of nitric oxide in the migration of endothelial cells. (Council of Scientific and Industrial Research (CSIR)). 2009
•Testing the potential of organosulfurs as drug to protect lungs from high altitude induced pulmonary edema using cell and animal tissue models (Defence Research and Development Organization (DRDO)) 2007
•Dissecting the mechanism of active metabolites of garlic in the activation of nitric oxide synthase in pulmonary artery endothelial cells under hypoxia (Defence Research and Development Organization (DRDO)) 2006
•Single cell investigations of the mechanical properties of human ventricular myocytes from biopsies Sri Ramchandra Medical College (SRMC), Chennai 2006
• Antifibrotic effects of BLX1015 and BLX1237 on activated hepatic stellate cells. Orchid Pharma (2010-2011)
• Targeting of antifibrogenic agents to hepatic stellate cells (HSC): A pilot consultancy project involving two drug candidates. Orchid Pharma (2010)
• Anti-angiogenic agents and methods of their use
International Filing: 11.04.2007
Inventors: Suvro Chatterjee (Anna University);Arunasalam Dharmarajan (Univ. of West. Australia
• N- substituted phthalimide derivatives as potential angiogenesis inhibitors
National Filing: 05.08.2011
Inventors: Bikram Singh (IHBT, Palampur); Suvro Chatterjee (Anna University); Neeraj
Kumar (IHBT, Palampur); Upendra Sharma (IHBT, Palampur)
• Interplanetary Travel G Simulator (IPTGS) (with CSIR);
A system based on a 3-D clinostat which is the simulator of weightlessness/microgravity as in space. With a centrifuge
attached to it makes it a simulator of hypogravity and hypergravity in one equipment.
The equipment modulates the gravity level ranging from 10^-5 g to 30 g and thus the
gravity at any point in the Universe can be simulated by this equipment.
Inventors: Suvro Chatterjee and Santosh Bhaskaran
File No. 591DEL2015
UGC-FRP Associate Professor, Centre for Biotechnology
Vascular Biology Lab, AU-KBC Research Centre
Anna University, Chennai 600025
044 - 2235 8362