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Department of Biotechnology Anna University

Dr. Sharmila Anishetty


Asst.Professor, Department of Biotechnology

Anna University, Chennai 600025
044 - 2235 8360

s_anishetty@annauniv.edu








Education

Degree Year University Major Subject Studied
Ph D 2005 Anna University, Chennai Computational Biology
M. Sc. 1984 Osmania University, Hyderabad Biochemistry
B. Sc. 1982 Osmania University, Hyderabad Botany, Zoology and Chemistry

Experience

Dec 2009 - Till Date Assistant Professor, Centre for Biotechnology, Anna University, Chennai
Jan 2006 - Nov 2009 Member Research Staff, Centre for Biotechnology, Anna University
Oct 2003 - Dec 2005 Technical Assistant, Centre for Biotechnology, Anna University, Chennai
Feb 2000 - Sep 2003 Member Research Staff, AU-KBC Research Centre, Anna University, Chennai
Dec 1999 - Jan 2000 Senior Software Engineer, Radiant Software Limited
Mar 1997 - Dec 1999 Systems Executive, Tata Infotech Limited (TULEC)
Aug 1996 - Feb 1997 Associate Systems Executive, Computer Point


Invited Lectures


Informatics in identification of potential drug targets and analysis. Organized by SVIMS Bioinformatics Centre, Tirupati, March 2017.
Bioprocessing India 2015. Organized by Department of Biotechnology, IIT-Madras, Chennai, December 2015.
New Perspectives in Biotechnology. Organized by Centre for Biotechnology in association with The University of Edinburgh, Centre for Biotechnology, Anna University, Chennai, February 2015.
Multi drug resistance in Mycobacterium tuberculosis: search for new targets and inhibitors. CRSI-IYC 2011, CLRI, Chennai, November 2011.
Mycobacterium tuberculosis Drug resistance, latency and the challenges ahead. Chennai chemistry conference, IIT-Madras, Chennai, February 2011.






Areas of specialization


• Protein Structure Studies

• Systems Biology

• Molecular Dynamics simulations of Enzymes

• Comparative Genomics


Research Guidance


No. of students completed Ph.D : 8

No. of students completed M.S. by Research : 2

Guided several B.Tech and M.Tech projects



Research projects


Co-investigator in 1 DST project (completed), Co-investigator in 3 DBT projects (completed), Co-investigator in 1 DBT project.





Publications


International Publications: 26

National: 1

Book chapters: 1

Conferences: International: 9, National: 1, Conference Journal Abstracts: 1

  • Priyadarsini Kadirvel, and Sharmila Anishetty. "Potential role of Salt-Bridges in the hinge-like movement of Apicomplexa specific β‐hairpin of Plasmodium and Toxoplasma profilins: A Molecular Dynamics Simulation Study." Journal of cellular biochemistry (2018) 119:3683-3696.
  • Sherlin Durairaj, and Sharmila Anishetty. "A pipeline for proteome-scale identification and studies on hormone sensitive lipases in Mycobacterium tuberculosis." Computational biology and chemistry 71 (2017): 201-206.
  • Maziya Ibrahim, Ahalyaa Subramanian, and Sharmila Anishetty. Comparative pan genome analysis of oral Prevotella species implicated in periodontitis. Functional & Integrative Genomics 17, (2017): 513.
  • Shobana Sundar, David Annaraj, Anitha Selvan, Pallavi Guha Biswas, Reshma Vijayakumaran and Sharmila Anishetty. Functional insights from a comparative study on the dynamics of Antigen85 proteins and MPT51 from Mycobacterium tuberculosis. Journal of molecular modelling 21, 12 (2015): 310.
  • Anitha Selvan, and Sharmila Anishetty. Cavities create a potential back door in epoxide hydrolase Rv1938 from Mycobacterium tuberculosis—A molecular dynamics simulation study. Computational biology and chemistry 58 (2015): 222-230.
  • Sherlin Durairaj, and Sharmila Anishetty. Mechanistic insights from molecular dynamic simulation of Rv0045c esterase in Mycobacterium tuberculosis. Journal of molecular modeling 21, no. 4 (2015): 1-8.
  • Singaravelu Muthukumar, Anitha Selvan, and Sharmila Anishetty. Molecular dynamics simulations of lectin domain of FimH and immunoinformatics for the design of potential vaccine candidates. Computational biology and chemistry 52 (2014): 18-24.
  • Singaravelu Muthukumar, Kirubagaran Ramalingam, and Sharmila Anishetty. In silico analysis of adhesive foot proteins of mussels. INDIAN J. MAR. SCI43, no. 11 (2014).
  • Jayakumar J, Anishetty S. Molecular Dynamics simulations of Inhibitor of Apoptosis Proteins and identification of potential small molecule inhibitors. Bioorg Med Chem Lett. 2014 May 1;24(9):2098-104.
  • Murahari P, Anishetty S, Pennathur G. Understanding the lid movements of LolA in Escherichia coli using molecular dynamics simulation and in silico point mutation. Comput Biol Chem. 2013 Dec;47:71-80.
  • BinnyPriya S, Saha S, Anishetty R, Anishetty S. A matrix based algorithm for Protein-Protein Interaction prediction using Domain-Domain Associations. J Theor Biol. 2013 Jun 7;326:36-42.
  • Ibrahim M, Anishetty S. A meta-metabolome network of carbohydrate metabolism: interactions between gut microbiota and host. BiochemBiophys Res Commun. 2012 Nov 16;428(2):278-84.
  • Selvaraj S, Sambandam V, Sardar D, Anishetty S. In silico analysis of DosR regulon proteins of Mycobacterium tuberculosis. Gene. 2012 Sep 10;506(1):233-41.
  • Selvan A, Seniya C, Chandrasekaran SN, Siddharth N, Anishetty S, Pennathur G. Molecular dynamics simulations of human and dog gastric lipases: insights into domain movements. FEBS Lett. 2010 Nov 19;584(22):4599-605.
  • Mohan, Abhilash, Sharmila Anishetty, and Pennathur Gautam. Global metal-ion binding protein fingerprint: A method to identify motif-less metal-ion binding proteins. Journal of Bioinformatics and Computational Biology 8.04 (2010): 717-726.
  • Krishna V, Kumar KS, Anishetty S, Pennathur G. Investigations on domain movements of N-acetyltransferase in nano scale. J NanosciNanotechnol. 2009 Sep;9(9):5493-6.
  • Majumder S, Rajaram M, Muley A, Reddy HS, Tamilarasan KP, Kolluru GK, Sinha S,Siamwala JH, Gupta R, Ilavarasan R, Venkataraman S, Sivakumar KC, Anishetty S,Kumar PG, Chatterjee S. Thalidomide attenuates nitric oxide-driven angiogenesis by interacting with soluble guanylyl cyclase. Br J Pharmacol. 2009 Dec;158(7):1720-34.
  • Kaushik Ramakrishnan S, Vinatha Krishna, Vinod kumar KS, Lakshmi BS, Sharmila Anishetty, GautamPennathur. Molecular dynamics simulations of lipases. (2008) International Journal of Integrative Biology, 2(3): 204-213.
  • Kadalmani K, Deepa S, Bagavathi S, Anishetty S, Thangaraj K, Gajalakshmi P. Independent origin of 185delAG BRCA1 mutation in an Indian family. Neoplasma. 2007;54(1):51-6.
  • Thilakaraj R, Raghunathan K, Anishetty S, Pennathur G. In silico identification of putative metal binding motifs. Bioinformatics. 2007 Feb 1;23(3):267-71.
  • Anishetty S, Pennathur G. Distribution of tripeptides in MHC binding peptides. Protein Pept Lett. 2007;14(6):552-6.
  • Anishetty S, Anishetty R, Pennathur G. Understanding mutations and protein stability through tripeptides. FEBS Lett. 2006 Apr 3;580(8):2071-80.
  • Anishetty S, Pulimi M, Pennathur G. Potential drug targets in Mycobacterium tuberculosis through metabolic pathway analysis. ComputBiol Chem. 2005 Oct;29(5):368-78.
  • Cherukuvada SL, Seshasayee AS, Raghunathan K, Anishetty S, Pennathur G. Evidence of a double-lid movement in Pseudomonas aeruginosa lipase: insights from molecular dynamics simulations. PLoSComput Biol. 2005 Aug;1(3):e28.
  • Santhiya ST, Manisastry SM, Rawlley D, Malathi R, Anishetty S, Gopinath PM, Vijayalakshmi P, Namperumalsamy P, Adamski J, Graw J. Mutation analysis of congenital cataracts in Indian families: identification of SNPS and a new causative allele in CRYBB2 gene. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3599-607.
  • Giri AV, Anishetty S, Gautam P. Functionally specified protein signatures distinctive for each of the different blue copper proteins. BMC Bioinformatics. 2004 Sep 9;5:127.
  • Anishetty S, Pennathur G, Anishetty R. Tripeptide analysis of protein structures. BMC Struct Biol. 2002 Dec 21;2:9.




Book chapters


  • Ahalyaa Subramanian, Maziya Ibrahim and Sharmila Anishetty, 2017, "Computational Approaches for Metal-Binding Site Prediction and Design of Effective Metal Bioremediation Strategies". In "Handbook of Metal-Microbe Interactions and Bioremediation". CRC Press. 393-400. ISBN: 978-1-4987-6242-7.

Journal Abstracts(Conference Proceedings)


  • Tanu Goyal and Sharmila Anishetty, An in silico study on molecular level interactions of host Siderocalin with siderophores from Mycobacterium tuberculosis and other bacterial species. BMC Infectious Diseases.2014 14(Suppl 3):O15.




Honors and Awards


• University First Rank in M.Sc. Biochemistry

• TATA Certified faculty in UNIX, C and Oracle.







Contact


Asst.Professor, Centre for Biotechnology

Anna University, Chennai 600025

s_anishetty@annauniv.edu

044 - 2235 8360