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Department of Biotechnology Anna University

Dr. Ramachandran Palpandi Raja

Assistant Professor, Centre for Food Technology

Department of Biotechnology

Anna University, Chennai 600025

044 - 2235 8387

palpandiraja@annauniv.edu,      palpandi@gmail.com


Ph.D. Chemical Engineering, Indian Institute of Technology Bombay, 2007 Thesis: Studies on liquid phase oxygen supply in fermentation processes Supervisor: Prof. Santosh B. Noronha
M. Tech Biotechnology, Anna University, Chennai, 2001 Thesis: Optimal fermentation strategies for improving insecticidal endotoxin production in Bacillus thuringiensis var.gallariae Supervisor: Prof. Kunthala Jayaraman
B. Pharm, Madurai Medical College, Madurai, 1998 Dissertation: Simultaneous spectrophotometric determination of ciprofloxacin and tinidazole in combined dosage forms Supervisor: Prof. John Thiruthuvadas

Professional Experience

Assistant Professor, Centre for Biotechnology, Anna University Chennai (December 2009 – Present)
Scientist, Microbial Process Development Division, Avestha Gengraine Technologies Pvt Ltd, ITPL, Bangalore (December 2007 – Present)

Research interests

My main research interests are Drug Delivery Engineering and Sustainable Bioprocessing. In our lab we study the fundamental understanding, monitoring and control of physicochemical phenomena in fermentation processes to achieve optimal and sustainable manufacturing of nutraceuticals and therapeutic products. We are also pursuing development of novel Drug Delivery Systems based on polymeric carriers.

Research Summary

Doctoral work was on studies to improve oxygen transfer in fermentation processes using liquid phase oxygen supply methodology, where the use of hydrogen peroxide as a source of oxygen supply to high cell density Pichia pastoris fermentations for recombinant human serum albumin production. The efficacy of liquid phase oxygen supply was compared to aeration in viscous xanthan gum fermentation and shear sensitive pellet mold cultivations. The productivities of enzymes such as catalase, and protease from Aspergillus niger were studied using various oxygen supply methodologies. Xanthan gum productivities in Xanthomonas campestris were studied under various oxygen supply regimes.

We have investigated various approaches for improving dissolved oxygen control in fermentation processes. As part of it a novel adaptive model predictive control algorithm for dissolved oxygen control was successfully implemented in high cell density recombinant methylotrophic yeast and bacterial cultivations. Monitoring and control of methanol level in a recombinant methylotrophic yeast fermentation process was automated using a gas sensor. I have also investigated strategies for improving lactic acid fermentation by controlling culture redox potential.

At Avesthagen for scale-up of a process for PUFA enriched single cell oil production from a marine protest and also part of team involved in the bioprocess development for recombinant proteins production using E.coli and Pichia pastoris.

Sponsored Research Projects

• 1.Co-investigator for the DBT sponsored research Project, “Metabolic engineering of Bacillus megaterium for enhanced production of pantothenic acid and its applications for the development of functional foods”

• 2.Co-investigator for the DST-SERB Sponsored Project, “Metabolic Engineering Pichia pastoris for the production of glucaric acid”

Research Publications

  • R. Palpandi Raja, Abhijit Badwe, Sachin C. Patwardhan, Santosh B. Noronha, ”Adaptive Model Predictive Control Of Dissolved Oxygen In A Bioreactor” Proceedings of the 8th International IFAC Symposium on Dynamics and Control of Process Systems Vol.3, 55-60 (2007)

Conferences/Seminars/Winter/Summer Schools attended

  • Workshop on “Futuristic Food requirements for Armed Forces” held at Defense Food Research Laboratory (DFRL), Mysore on 2010.
  • Institute-Industry workshop on “Food Science Education and Research” held at Banaras Hindu University (BHU), Varanasi on 7-8th April 2010
  • “Biotechnology: Indian and UK Perspectives”, Seminar jointly organized by Centre for Biotechnology, Anna University and British Council, Chennai, 13 – 14 October, 2011
  • 23rd National Congress of Indian Society for Parasitology, held at Centre for Biotechnology, Anna University November 18 – 20, 2011
  • AICTE sponsored Faculty Development Program on Fluid Mechanics and Machinery at the Department of Automobile Engineering, MIT, Anna University from 01/06/2011 to 08/06/2011
  • AICTE sponsored Staff Development Program on Fundamentals of Nanoscience and Technology at the Crystal Growth Centre, Anna University from 07/12/2011 to 21/12/2011
  • AICTE Faculty Development Program on Composite Materials at the Department of Rubber and Plastics Technology from 16/05/2012 to 23/05/2012
  • AICTE Sponsored Faculty Development Program on Industrial Instrumentation at the Department of Instrumentation Engineering from 28/05/2012 to 03/06/2012


Assistant Professor, Centre for Biotechnology

Department of Biotechnology

Anna University, Chennai 600025


044 - 2235 8387