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Department of Biotechnology Anna University

Dr. Anuradha Dhanasekaran


Director, Centre for Biotechnology


Head, Department of Biotechnology


Anna University, Chennai 600025

044 - 22358384


anushivan@gmail.com








Stem Cell Technology and Cancer Biology Laboratory


Stem cell Technology is the Holy Grail of therapeutic intervention, offering a plethora of unique applications. I use cell signalling approaches to characterize and validate this technology in the context of disease models especially cardiovascular disorders .

My early research career at the Medical College of Wisconsin demonstrated for the first time the capacity of EETs to enhance human endothelial cell survival by inhibiting both the intrinsic, as well as extrinsic, pathways of apoptosis, an important underlying mechanism that may promote angiogenesis and endothelial survival during atherosclerosis and related cardiovascular ailments. This contribution to the protection of cardiomyocytes is highly significant because of its importance in the medical field especially in the treatment of diseases. This came as a spin-off for my interest in cardiomyocyte regeneration and interest in stem cells as a potential therapeutic agent.

I had the honor and priviledge of being trained in the lab of WiCell , a unit of Dr James Thomson , in Wisconsin and that is when stem cell research enthused me and since then I have been working in Stem cell technology in collaboration with Dr John Lough, Dr Zeljko Bosjnak from Medical College of Wisconsin. I also was awarded a DST- UKIERI project in Collaboration with Dr Eustace Johnson , University of Chester, U.K . My lab at Center for Biotechnology, Anna University is mainly focused on basic research in stem cells and differentiating them towards cardiac lineage and research also focusses on Cancer Stem cells. We are successful in isolating adult cardiac stem cells (CSCs) from a rodent model. CSCs were differentiated to cardiomyocytes using combination of epigenetic modifier - 5-Azacytidine and small molecule – Ascorbic acid. Differentiated cardiomyocytes were structurally and functionally analyzed for derivation of cardiomyogenic lineage. Studies on transplantation of differentiated cardiomyocytes in small animal myocardial injury model are being planned.

Hence my overall interest in cardiovascular research emanates from the point that there is no effective strategies or therapeutics to combat this disease. Having worked in cardiomyocyte cell death and ischemic injury for more than twenty years and I am beginning to understand the mechanisms and working on therapeutics and cell repair and replacement by stem cell therapy which might protect the cardiomyocyte apoptosis and cardiac repair in cardiovascular disorders.



Education

Degree Year University Major Subject Studied
M.Sc 1988-90 University of Madras Biochemistry
M.Phil 1990-91 University of Madras Biochemistry
PhD 1991-95 University of Madras Biochemistry

Post Doctoral Experience

Mar 1997-May 1998 Institute For Medical Microbiology and Hygiene, Johannes Gutenberg University, Mainz, GERMANY
Oct1998-Feb 2001 Regional Environment Division, National Institute for Environmental Studies, Tsukuba, JAPAN
Aug 2002-July 2004 Free Radical Research Center, Medical College Of Wisconsin, Milwaukee,Wisconsin, USA
Aug 2004-Nov 2009 Cardiovascular Research Center, Medical College Of Wisconsin, Milwaukee,Wisconsin, USA
Dec 2009-April 2012 Assistant Professor, Centre for Biotechnology, Anna University, Chennai, INDIA
April 2012– Till date Assistant Professor, Centre for Biotechnology, Anna University, Chennai, INDIA


Professional Experience


Underwent training in Instrumentation and Molecular biology techniques in National Research Council (CNR), Italy for two months
Attended a workshop on Molecular Oncology conducted by Cancer Biology Division of Madurai Kamaraj University, India and had  hands on training in all molecular biologytechniques
Worked as a Post doctoral fellow in Johannes Gutenberg University,Germany and worked on NF kappa B activation in response to acute toxins
Worked as a STA fellow at NIES, Japan on the gene expression of Krox-20 in response to adhesion in macrophages and apoptotic pathway in HL-60 cells on NaF exposure
Worked as a Post doctoral fellow in Free radical research Center Medical College of Wisconsin on the effect doxorubicin,an anticancer drug on BAEC cells and their intervention by mitochondrially targeted drugs –Mitoquinone and mitonitroxide.
Worked as Research Associate in Pulmonary and Critical Care Division,Medical College of Wisconsin on the protective role of eicosanoids in apoptosis and angiogenesis.


Position in Professional Bodies


ANNA UNIVERSITY NOMINEE for JRF recruitments at Anna University.
Coordinator , DBT –Builder Program Funded by Department of Biotechnology , New Delhi.
Member of national screening committee for the selection of Fulbright-Nehru Post-Doctoral Grant applicants in the area of Science and Technology sponsored by USIEF.
Co-Coordinator , University Innovation Cluster, DBT, New Delhi
Coordinator/Member of Inspection Committee-Infrastructure facilities in the R&D Labs
Expert Member, Review Team of Department of Scientific & Industrial Research(DSIR), Ministry of Science &Technology, Govt.of India, New Delhi.
DBT Nominee, Instituitional Biosafety Committee, IIT, Madras.
DBT Nominee, Instituitional Biosafety Committee, Appasamy Occular Devices Pvt Ltd, Chennai
Expert member,Instituitonal Ethical Committee, Apollo Hospitals, Chennai.
Member of the Institutional Committee for Stem Cell Research & Therapy(IC-SCRT)-JIPMER, Puducherry.
Member of the Institutional Committee for Stem Cell Research & Therapy(IC-SCRT)- M.V.Diabetes Center, Chennai
Member of the Institutional Committee for Stem Cell Research & Therapy(IC-SCRT)-Apollo Hospitals, Chennai.
Nominated as a Member of Selection Committee-Science City-Department of Higher Education, Government of Tamilnadu.
Member, Selection Committee, DBT-TWAS
Member of Research Advisory Committee-Institute of Bio- Medical Research,Chennai.
Member of the National Advisory Committee in the International conferences on Advances in Biotechnology and Biotherapeutics (ICABB-2017)
Nominated as an Expert Member, Board of Studies-Anna University –Thiruchirappalli. rajala
Member, Board of Studies-Vivekanandha College of Engineering for Women. Tiruchengode.
Member, Board of Studies -Karapagam Academy of Higher Education- Coimbatore
Member, Board of Studies, Sri Ramachandra University, Porur, Chennai
Academic Council Member, Mother Theresa University, Kodaikanal.
Chairman/Member of Inspection Committee-Anna University Affiliation Colleges.
Member,Scientific Committee, Science City, Chennai
Member for the Departmental Consultative Committee (DCC).
Doctoral Advisory Committee-Academy of Scientific Innovative Research-CLRI
Doctoral Committee Member ,Thesis Examiner and Viva Voce Examiner – IICT, IIT, Manipal University, SRM University, VIT University, University of Madras ,Annamalai University


Countries Visited


Name of the Country Purpose Year Duration
University of Edinburgh, Scotland, UK Erasmus Staff mobility July 2017 One Week
Medical College of Wisconsin Milwaukee, USA Visiting Faculty July 2016 One month
University of Chester Chester, UK UKIERI collaborative project September 2016 One week
University of Ghent, Ghent, Belgium Erasmus-Mundus Fellow April 2015 One month
Kansas University Medical Center Cardiovascular Research Institute –The University of Kansas USA Research Collaboration May 2014 One month
Aston University,Birmingham, United Kingdom Collaborative project under UKIERI scheme July 2014 One week
Medical college of Wisconsin-Department of Cell biology, Neurobiology Anatomy USA Research Collaboration August 2013 One month
Nigeria University Representative June 2013 Four days
Harbin Medical University, China Research Collaboration June 2012 Two months
Medical College of Wisconsin-Department of Radiation Oncology, USA Research Collaboration November 2012 One month
Cardiovascular Research Center, Medical College Of Wisconsin, Milwaukee,Wisconsin, USA Post-Doctoral Fellow Nov 2004-2009 Five years
Free Radical Research Center, Medical College Of Wisconsin, Milwaukee,Wisconsin, USA Post-Doctoral Fellow July 2002-2004 Two years
Regional Environment Division, National Institute for Environmental Studies, Tsukuba, JAPAN Post-Doctoral Fellow Feb 1998-2001 Three years
Institute For Medical Microbiology and Hygiene, Johannes Gutenberg University, Mainz, GERMANY Post-Doctoral Fellow May 1996-1997 One year
National Research Council (CNR), Italy Underwent training August 1995 Two months


360° Virtual Lab View








Areas of Expertise


• Tissue Engineering

• Angiogenesis

• Cell signalling

• Hypoxia

• Stem cell Technology

• Cardiovascular Therapy



Stem cell Technology


• To create a platform that fosters inter-disciplinary collaborations toward bench to bedside translation of stem cell technologies for heart and vascular disease management

• To study the role of Wnt signaling in Stem cell differentiation

• Role of conditioned media from MScs

• Effects of micro-environmental stress on the regenerative activity of mesenchymal stem cells.

My lab focuses on further understanding of stem cell behavior, characterization, manipulation, expansion and therapeutic delivery

Cardiovascular Therapeutics


• In vitro studies in enhancing CSCs survival, proliferation and subsequent differentiation to functional Cardiomyocytes under hypoxic conditions.

• Analysis of anti-apoptotic and cyto protective pathways give clue regarding molecular mechanisms involved in decreasing the extent of cell death.

• Isolation, culture and characterization of CSCs from rat heart biopsies by explant method



Cancer Biology


• Understanding the signaling mechanisms in Cancer stem cells

• Mitochondrially targeted compounds novel therapeutic agents for Cancer novel therapeutic agents for Cancer

• Tumour Angiogenesis

Our goal is to understand the mechanism of tumor derived cytokines recruits and regulates the fate of infiltrating stem cells and how these cells affect tumor progression. We are focused in genetic and metabolic profiling that occur in tumor and MSCs.



Ongoing Projects


Organisation Title of the project Role Amount in Lakhs
DST-UKIERI Principal Investigator (India) The effects of micro-environmental stress on the regenerative activity of mesenchymal stem cells Principal Investigator 18 lacs
MHRD CEMA Project Investigator Tissue Engineering Osteoblasts and Human Dermal fibroblasts on PCL electrospun matrices Principal Investigator 12 crores
DBT –BUILDER Coordinator and Project Investigator In vitro differentiation of mesenchymal stem cells into epithelial cell lineage - Clues from Gene profiling analysis Co-ordinator 10.46 Crores
DST –SERB Principal Investigator Effects of 20-HETE in mediating VEGF and No- I induced changes in tissues by distinct signaling mechanis Principal Investigator 54 lacs


Invited Lectures


Delivered more than 75 lectures as plenary speaker, Invited speaker and Keynote speaker both National and International.



Membership and Positions in Professional Bodies


• Reviewer for Elsevier Publications

• Reviewer, PLOS journals

• Member of  Animal Ethical Committee, Anna University

• Member of national screening committee for the selection of Fulbright-Nehru Post-Doctoral Grant applicants in the area of Science and Technology sponsored by USIEF

• Member of Japanese Biochemical Society

• Member of American Heart Association

• Expert Member, Institutional Committee for Stem Cell Research and Therapy (IC-SCRT,JIPMER, India


No of Students Guided:

Ph D - 5

M.S (By Research)- 4

 M.Tech-25

No of Students currently guiding:

PhD- 8

M.Tech -5





Selected Publications


  • Mundre RS1, Koka P1, Dhanaraj P1, Khatri N1, Vig S1, Chandramohan Y1, Dhanasekaran A1. Synergistic role of 5-azacytidine and ascorbic acid in directing cardiosphere derived cells to cardiomyocytes in vitro by downregulating Wnt signaling pathway via phosphorylation of β-catenin. PLoS One. 2017 Nov 30;12(11):e0188805. doi: 10.1371
  • Variar G, Pant T, Singh A, Ravichandran A, Swami S, Kalyanaraman B, Dhanasekaran A. Effect of mitochondrially targeted carboxy proxyl nitroxide on Akt-mediated survival in Daudi cells: Significance of a dual mode of action. PLoS One. 2017 Apr 20;12(4)
  • Samanta S, Balasubramanian S, Rajasingh S, Patel U, Dhanasekaran A, Dawn B, Rajasingh . MicroRNA: A new therapeutic strategy for cardiovascular diseases. J.Trends in cardiovascular medicine,March 2016. DOI: 10.1016/j.tcm.2016.02.004.
  • Jeeva Jothi D, M Dhanraj, S Solaiappan, S Sivanesan, M Kron, A Dhanasekaran, "Brugia malayi Asparaginyl-tRNA Synthetase Stimulates Endothelial Cell Proliferation, Vasodilation and Angiogenesis", PLOS ONE, published by PLOS ONE. Vol. 11, Issue 1, pp. 1-12 (2016).
  • Asiya Parvin A, Rohini Rangarajan, Pavani Koka, Raj K Bala, Reddy Sailaja,Mubeen Fathima,Jeeva Jothi D, Sanjana Sivanesan, John E Baker, Anuradha Dhanasekaran, Recombinant Erythropoietin Mitigates Injury fromIschemia/Reperfusion in Neonatal Cardiomyocytes by Novel Multiple Signalling Pathways. Int J Pharm Pharm Sci (2015)
  • Asiya Parvin A, John E Baker, Anuradha Dhanasekaran. Erythropoietin receptor mRNA expression in Human Cardiomyocytes. Journal of Biochemical Sciences, 2 (2015)
  • Asiya Parvin A, Anuradha Dhanasekaran. Erythropoietin Regulation on p38 MAPK and Downstream targets of Akt during Hypoxia/Reperfusion injury on H9C2 cells. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6 (5) (2015).
  • John E. Baker, Jidong Su, Stacy Koprowski, Anuradha Dhanasekaran, Tom P. Aufderheide, and Garrett J. Gross, " Thrombopoietin Receptor Agonists Protect Human Cardiac Myocytes from Injury by Activation of Cell Survival Pathways", J Pharmacol Exp Ther, published by The American Society for Pharmacology and Experi. pp. 429-437 (2014).
  • A Parvin, U Shalini, A Devendran, JE Baker, A Dhanasekaran, "Erythropoietin protects cardiomyocytes from cell death during hypoxia/reperfusion injury through activation of survival signaling pathways", PLOS ONE, published by PLOS ONE. Vol. 9, Issue 9, pp. 1-12 (2014).
  • A. Murugesan, T. Vidhyadevi, S.S. Kalaivani, P. Baskaralingam, C.D. Anuradha and S. Sivanesan", Kinetic studies and isotherm modeling for the removal of Ni2+ and Pb2+ ions by modified activated carbon using sulfuric acid", Environmental Progress & Sustainable Energy, published by Wiley Online library. Vol. 33, Issue 3, pp. 844-854 (2013).
  • T. Vidhyadevi, A. Murugesan, S.S. Kalaivani, M. Anil Kumar, K.V. Thiruvenkada Ravi, L. Ravikumar, C.D. Anuradha, S. Sivanesan, "Optimization of the process parameters for the removal of reactive yellow dye by the low cost Setariaverticillata carbon using response surface methodology: Thermodynamic, kinetic, and equilibrium stu", Environmental Progress & Sustainable Energy, published by Wiley Online library. Vol. 33, Issue 3, pp. 855-865 (2013).
  • ER Jacobs, S Bodiga, I Ali, AM Falck, JR Falck, M Medhora, A Dhanasekaran, " Tissue protection and endothelial cell signaling by 20-HETE analogs in intact ex vivo lung slices", Experimental Cell Research, published by elsevier. Vol. 318, Issue 16, pp. 2143-2152 (2012).
  • Anuradha Dhanasekaran Sreedhar Bodiga , Stephanie Gruenloh , Ying Gao , Laurel Dunn, John R. Falck , J. Noelle Buonaccorsi , Meetha Medhora , Elizabeth R. Jacobs, " 20-HETE increases survival and decreases apoptosis in pulmonary arteries and pulmonary artery endothelial cells", American Journal of Physiology-Heart and Circulatory Physiology , published by American Physiological Society. Vol. 296, Issue 3, pp. H777-H786 (2009).
  • Anuradha Dhanasekaran , Stephanie K. Gruenloh , J. Noelle Buonaccorsi , Rong Zhang , Garrett J. Gross , John R. Falck , Paresh K. Patel , Elizabeth R. Jacobs , Meetha Medhora, "Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia", American Journal of Physiology-Heart and Circulatory Physiology , published by American Physiological Society. Vol. 294, Issue 2, pp. H724-H735 (2008).
  • Meetha Medhora , Anuradha Dhanasekaran , Phillip F. Pratt Jr., Craig R. Cook , Laurel K. Dunn, Stephanie K. Gruenloh , Elizabeth R. Jacobs, " Role of JNK in network formation of human lung microvascular endothelial cells", American Journal of Physiology-Lung Cellular and Molecular Physiology , published by American Physiological Society. Vol. 294, Issue 4, pp. L676-L685 (2008).
  • A Dhanasekaran, S Gruenloh, R Zhang, G Gross, J Falck, E Jacobs, M Medhora, "Epoxyeicosatrienoic acids (EETs) block cardiomyocyte cell death from hypoxia/reoxygenation injury via the PI3K/Akt survival pathway", FASEB, published by FASEB. Vol. 21, Issue 6, pp. A1288-A1288 (2007).
  • A Dhanasekaran, R Al-Saghir, B Lopez, D Zhu, DD Gutterman, ER Jacobs, M Medhora, " Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature", American Journal of Physiology-Heart and Circulatory Physiology , published by American Physiological Society. Vol. 29, (2006).
  • A Dhanasekaran, R Al-Saghir, B Lopez, D Zhu, DD Gutterman, ER Jacobs, M Medhora, " Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature", American Journal of Physiology-Heart and Circulatory Physiology , published by American Physiological Society. Vol. 29, (2006).
  • A Dhanasekaran, S Gruenloh, E Jacobs, M Medhora, "Epoxyeicosatrienoic acids (EETs) protect cardiovascular cells from apoptosis mediated by caspase 3-dependent pathways", FASEB, published by FASEB. Vol. 20, Issue 4, pp. A123-A123 (2006).
  • Anuradha Dhanasekaran, Srigiridhar Kotamraju, Chandran Karunakaran, Shasi V. Kalivendi, Simmy Thomas, Joy Joseph, B. Kalyanaraman, " Mitochondria superoxide dismutase mimetic inhibits peroxide-induced oxidative damage and apoptosis: role of mitochondrial superoxide", Free Radical Biology and Medicine , published by Elsevier. Vol. 39, Issue 5, pp. 567-583 (2005).
  • Dhanasekaran A, Kotamraju S, Kalivendi SV, Matsunaga T, Shang T, Keszler A, Joseph J, Kalyanaraman B., "Supplementation of endothelial cells with mitochondria-targeted antioxidants inhibit peroxide-induced mitochondrial iron uptake, oxidative damage, and apoptosis", The journal of biological chemistry, published by JBC Papers. Vol. 279, Issue 36, pp. The journal of biological chemistry (2004).
  • T Matsunaga, S Kotamraju, SV Kalivendi, A Dhanasekaran, J Joseph, B Kalyanaraman, "Ceramide-induced Intracellular Oxidant Formation, Iron Signaling, and Apoptosis in Endothelial Cells PROTECTIVE ROLE OF ENDOGENOUS NITRIC OXIDE", Journal of Biological Chemistry , published by y The American Society for Biochemistry and Molecu. Vol. 279, Issue 27,pp. 28614-28624 (2004).
  • A Shraim, NC Sekaran, CD Anuradha, S Hirano, "Speciation of arsenic in tube-well water samples collected from West Bengal, India, by high-performance liquid chromatography–inductively coupled plasma mass spectrometry", Applied Organometallic Chemistry , published by FEB. Vol. 16,Issue 4, pp. 202-209 (2002).
  • S Hirano, CD Anuradha, S Kanno, "krox20/egr2 is upregulated following non‐specific and homophilic adhesion in ratmacrophages", Immunology, Vol. 107, Issue 1, pp. 86-92 (2002).
  • Y Dragneva, CD Anuradha, A Valeva, A Hoffmann, S Bhakdi, M Husmann, " Subcytocidal attack by staphylococcal alpha-toxin activates NF-κB and induces interleukin-8 production", Infection and immunity , Vol. 69, Issue 4, pp. 2630-2635 (2001).
  • S Kanno, CD Anuradha, S Hirano, "Localization of zinc after in vitro mineralization in osteoblastic cells", pp. springer (2001).
  • S Kanno, CD Anuradha, S Hirano, " Chemotactic responses of osteoblastic MC3T3-E1 cells toward zinc chloride", Biological Trace Element Research , published by Springer. Vol. 83, Issue 1, pp. 49-55 (2001).
  • CD Anuradha, S Kanno, S Hirano, " Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells", Free Radical Biology and Medicine, published by Elsevier. Vol. 31, Issue 3, pp. 367-373 (2001).
  • CD Anuradha, S Kanno, S Hirano, "Fluoride induces apoptosis by caspase-3 activation in human leukemia HL-60 cells", Archives of toxicology , published by Springer. Vol. 74, Issue 4, pp. 226-230 (2000).
  • CD Anuradha, S Kanno, S Hirano, " RGD peptide-induced apoptosis in human leukemia HL-60 cells requires caspase-3 activation", Cell biology and toxicology , published by Springer. Vol. 16, Issue 5, pp. 275-283 (2000).
  • S Hirano, CD Anuradha, S Kanno, " Transcription of krox-20/egr-2 is upregulated after exposure to fibrous particles and adhesion in rat alveolar macrophages", American journal of respiratory cell and molecular biology , published by Am Thoracic Soc. Vol. 23, Issue 3, pp. 313-319 (2000).
  • CD Anuradha, S Hirano, SHYAMALA DEVI C. S., "Studies on the nature and significance of collagen in experimentally induced oralsubmucous fibrosis in rats", Journal of clinical biochemistry and nutrition , Vol. 27, Issue 3, pp. 123-130 (1999).
  • CD Anuradha, S Kanno, S Hirano, "Studies on the hematological profile and trace elements in oral submucous fibrosis", Journal of clinical biochemistry and nutrition , Vol. 19, Issue 1, pp. 9-17 (1995).


Significant Papers Presented in Conferences


  • Sathyamoorthy Balasubramanian, J. Thangavel, K.N.Dileepan, A.Dhanasekaran, B.Dawn and J.Rajasingh. Combinatorial treatment with epigenetic modifiers inhibits thrombin- induced eNOS/RhoA signaling and restores AJ integrity. Experimental Biology Annual meeting 2014, April 26-30 2014, San Diego , USA.
  • Jeeva Jothi Dhanasekaran, S.Solaiyappan, M. Dhanraj, S.Chatterjee, M.Kron and Anuradha Dhanasekaran. Expression and characterization of Asparagine- tRNA synthetase: the key enzyme that mediates angiogenesis in lymphatic filariasis. Experimental Biology Annual meeting 2014, April 26-30 2014, San Diego , USA
  • Rohini Rangarajan and Anuradha Dhanasekaran. Comparison and characterization of PVA/Vanillin scaffolds for tissue engineering applications. 12-14 March 2014, Vellore Institute of Technology, Vellore,India.
  • Abinayaa Ravichandran, Gokul Variar, Tarun Pant, Apoorva Singh and Anuradha Dhanasekaran. Hypoxia-induced apoptosis in HL-60 cells. A prelude to treatment with targeted compounds. 30th Jan-  1st Feb 2014, Cancercon, IIT Madras, India.
  • AsiyaParvinAllaudeen, AjayDevendran. John E Baker, Anuradha Dhanasekaran. Recombinant Human Erythropoietin Prevents Reactive Oxygen Species  - Induced Apoptosis Via  Akt and p38 MAPK Pathway During Hypoxia/ Reperfusion Injury.Basic Cardiovascular Sciences 2013 .American Heart Association- Circulation Research. Las Vegas,Nevada,USA July, 2013
  • ThiruvarutChelvan S, Johnson W E Anuradha Dhanasekaran. Role of secretion of MSCs in presence of Leptin. National conference on Biolife.Sanjay Gandhi Postgraduate Institute of Medical Sciences,Lucknow, India ,March 2013
  • Ruban Rex P, Johnson W E, Arumaikkannu G Anuradha Dhanasekaran. Analysis of a novel customizable polyamide scaffold to support osteoblast differentiationInvitro bio-compatability study. National conference on Biolife.Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.4,5th March 2013.
  • JeevaJothi D, SuvroChattergiee, Anuradha Dhanasekaran. Ap3A inhibits AsnRs-induced angiogenesis in Ehy926 endothelial cells. International workshop on wound healing & angiogenesis AU-KBC Research Centre, Chennai, India, December 2013
  • AsiyaParvin .A, Raj Pranp, Shalini.U Anuradha Dhanasekaran. “Erythropoietin receptor signaling in cardiomyocytes protection during hypoxia   reperfusion injury” along with National conference on “Impact of Biotechnology in Health care & Industry Vel Tech High Tech Dr.Rangarajan, Dr. Sakunthala Engineering College, Avadi, Chennai, India, 2011
  • JeevaJothi.D, Anuradha Dhanasekaran ‘Expression and purification of Asperhine-tRNA synthetases in lymphatic filariasis’, 23rd National congress on Parasitology,Anna University,  Chennai, India 2011
  • C.D.Anuradha,Kanno,S Seishiro Hirano Fluoride induces apoptosis by caspase-3 activation in HL-60 cells. Society of Toxicology Meeting Philadelphia, USA,Mar 2000
  • C.D.Anuradha,Kanno,S Seishiro Hirano RGD peptide- induced apoptosis in Human leukemia HL-60 cells requires caspase-3 activation 18th International Conference of Biochemistry and Molecular Biology (IUBMB) Birmingham, UK,July 2000
  • C.D.Anuradha, Kanno,S Seishiro Hirano Cytochrome-c release and caspase activation in NaF-induced apoptosis in HL-60 cells Gordon Research Conference-Mechanisms of Toxicity New Hampshire, USA, July 2000
  • C.D.Anuradha, Kanno,S Seishiro Hirano Fluoride induces apoptosis in HL-60 cells through a mechanism involving oxidative stress Gordon Research Conference-Oxidative stress and Diseases Los Angeles, USA, March 2001
  • C.D.Anuradha,Kanno,S Seishiro Hirano Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride induced apoptosis in HL-60 cells 40thSociety of Toxicology Meeting San Fransisco, USA, March 2001.
  • C.D.Anuradha,Kanno,S Seishiro Hirano Fluoride induces apoptosis in Human leukemia (HL-60) cells by down regulation of Bcl-2 ASBMB meeting on Experimental Biology Orlando, USA, April 2001.
  • C.D.Anuradha, SrigiridharKotamraju, Joseph J, Murphy MP, Kalyanaraman(2003):Supplementation of endothelial cells with mitochondrially-targeted ubiquinone derivative, MitoQ    inhibits H2O2-induced mitochondrial iron uptake and apoptosis Society for Free radicals in Biology and Medicine. Seattle, USA, Nov 2003
  • Anuradha Dhanasekaran, Stephanie K. Gruenloh, Elizabeth R. Jacobs and MeethaMedhora(2005). EETs protect microvascular endothelial cells from Fas-induced apoptosis. American Heart Association. Texas,USA 2005
  • Anuradha Dhanasekaran, Stephanie K. Gruenloh, Elizabeth R. Jacobs and MeethaMedhora (2005). EETs protect cardiomyocytes from hypoxia-reperfusion induced injury by a AKT-dependent pathway. FASEB meeting. San Fransisco, USA 2006.
  • Anuradha Dhanasekaran, Stephanie K. Gruenloh, Rong Zhang, Noelle Buonaccorsi, Elizabeth R. Jacobs and MeethaMedhora(2007) PI3K/Akt pathway is activated by epoxyeicosatrienoic acids (EETs) to protect cardiomyocytes from apoptosis induced by hypoxia/reoxygenation injury.
  • GORDON RESEARCH CONFERENCE‐Oxidative stress and Diseases.Ventura Beach,California 2007.

Conferences Organised


  • Organising Secretary, Current trends on Diagnostics and Therapeutics for Lifestyle Diseases, February 27th -28 ,2018.
  • Organising Secretary, Advances in Gene Editing, March 1-2 ,2017
  • Organizer, International conference on "Avidadham-2016- An International conference on Recent Advances in Diagnostics and Treatment of Metabolic Disorders “from March 18 &19-2016.
  • Organizer, One day Seminar on Stem Cells in Tissue Regeneration-Organized by Anna University & Aston University-DST-UKIERI, On October 2015.
  • Organizer, International conference on Contemporary Research Trends in Diagnostics and Therapeutics" from 16-Feb-2015 to 18-Feb-2015.
  • Organising Secretary, An International conference on frontiers and challenges in healthcare, Biotechnology and food processing Technology"from 03-Feb-2014 to 05-Feb-2014.
  • Organizing Secretary, International level conference on Molecular therapeutics organized by Anna University.
  • Organizer, International level seminar on "Biotechnology: UK and Indian Perspectives" from 13-Oct-2011 to 14-Oct-2011.
  • Organizing Secretary, National level conference on "National congress of Parasitology, jointly organized by the Indian Society for Parasitology and Anna University" November-2011.

Collaborators


BALARAMAN KALYANARAMAN, PhD
Chairman and Professor of Biophysics
Medical College of Wisconsin
USA
ELIZABETH ROGERS JACOBS, MD
Professor and Chief Pulmonary Medicine
Medical College of Wisconsin
USA
MICHAEL KRON, MD, MS
Dept of Medicine
Medical college of Wisconsin
USA
Dr MEETHA MEDHORA
Professor,
Radiation Oncology,
Medical College of Wisconsin
USA
JOHN E. BAKER PhD
Professor,
Department of Surgery
Division of Cardiothoracic
Medical College of Wisconsin
USA
RAJASINGH JOHNSON
Division of Cardiovascular Diseases
Kansas Medical Center Kansas
USA
EUSTACE JOHNSON PhD
Life and Health Sciences
Aston University
UK
ZELJKO J. BOSNJAK PhD
Professor
Department of Medicine Division of Endocrinology
Medical College of Wisconsin
USA




Awards


  • Prof M.Viswanathan Honor Award for the year 2017 in recognition of outstanding research
  • Was selected under Erasmus Exchange for staff mobility by European Union to attend workshop in University of Edinburgh, Scotland.
  • Active Researcher Award for outstanding contributions awarded by Center for Technology development and transfer(CTDT), Anna University, India (2015).
  • Visiting Fellow at Ghent University, Belgium March-April 2015 under SVAGATA Fellowship under Erasmus Mundus programme.
  • Award for Excellence in Research by Divisiion of Pulmonary and Critical care, Department of Medicine, Medical college of Wisconsin, USA ,2009.
  • Recipient of Svagata fellowship (2014-15) under the Erasmus Mundus Action 2 (EMA2) Svaagata.eu project to visit Ghent University, Belgium as Staff for a month.
  • "International Conference Travel grant " given by Anna University from India (2013)
  • Has been cited in Asia’s Who’s Who of Men & Women of Achievement 2010
  • Got the “MOST CITED PAPER AWARD” from Elsevier publications for the year “2005- 2007”.
  • Got the “BEST CLINICAL RESEARCH PRESENTATION AWARD” for best research presentation by the Department of Medicine, Medical College of Wisconsin during Research Day 2005.
  • Travel Award from the chair’s fund to present research findings at the GORDON RESEARCH CONFERENCE – Oxidative Stress and Disease in Los Angeles, USA, March 2001.
  • Young Scientist Travel Award was awarded to present at the ASBMB meeting on Experimental Biology in Orlando, USA, April 2001
  • Travel Award from the chair’s fund to present at the GORDON RESEARCH CONFERENCE – Mechanisms of Toxicity held in Newhampshire, Boston, July 2000
  • The American Society for Biochemistry and Molecular Biology Postdoctoral Travel Award program at Orlando, Florida in March 2001.
  • Science and Technology Agency Award by Japan Science and Technology Corporation and Japan International Science and Technology Exchange (JSPS) Center to work as a researcher in Japan in August-2000.
  • 18 th International Congress of Biochemistry and Molecular Biology Young Scientist Travel Fellowships Symposium in International conference centre Birmingham, UK-July 2000.
  • Has been cited in Marquis Whos Who in Medicine and Health care for the year 2001.
  • Science and Technology Agency Award by Japan Science and Technology Corporation and Japan International Science and Technology Exchange Center to work as a researcher in Japan in September 1998-2000.
  • As Course co-ordinator ,three courses, Antiparasite drug discovery and Targeting Cancer Metabolism and Redox Biology was approved by GIAN,(Global initiative for academic network)






Contact


Director, Centre for Biotechnology

Head, Department of Biotechnology

Anna University, Chennai 600025

anu@annauniv.edu
anushivan@gmail.com

044-22358384

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